I've gone back to using my Emu 1212m for the audio interface. Actually, I never stopped using it, as I used it with Scope cards and Scope Xite-1. Not really necessary when using Scope, but handy. With Scope gone, it has saved my ass, at least as far as doing digital audio. It's now available in both PCI and PCIe configurations. Totally professional digital sound interface, mixer, router. Limited but OK-in-a-pinch DSP effects. Fairly inexpensive ($170 from Sweetwater).
http://www.sweetwater.com/store/detail/1212MPCIe/

My synth solution is the amazing E-mu Emulator X3 software sampler. It works great on my multi core, Windows 7/64 setup. It's just as powerful as the hardware version it emulates, which is arguably the best sampler ever made. Here is the E-mu website blurb:
http://www.emu.com/products/product.asp ... v=featuresE-MU's Emulator® X3 is the world's most powerful and complete software sampling tool in the world, featuring E-MU's new Xstream™ streaming sound engine with a up to 192kHz sampling and playback, 32-bit and 64-bit native applications for both Windows XP and Windows Vista, an arsenal of automated sampling/beat analysis/editing tools and almost unlimited sound manipulation that builds on E-MU's 35 years of synthesis experience.
E-mu lists it at $700 but it generally sells for $500, and if you look around you can get it for a lot less. I got mine at B&H for $180.
http://www.bhphotovideo.com/c/product/6 ... or_X3.html
Also, there are some great sample libraries, taken from both the E-mu Proteus series and all their hardware samplers, plus the libraries from the Ensonic samplers. All in all a terrific and inexpensive source of cool sounds. Available from Digital Sound Factory, which basically is the person who produced most of the original E-mu samples:
http://www.digitalsoundfactory.com/
You can hear some of these sounds in my "Ten Minutes of Cold" .mp3 piece:
http://algoart.com/music.htm
Full Disclosure: Although I no longer work for E-mu and have not for many years (since before it was bought out by Creative), I do have a history with them going all the way back to when they produced Modular synths. I soldered modules together, did a little design work on the digital modules, and wrote some of the first sequencer code for them as well as programs to edit the Proteus and Morphius series samp/synths. So I might be a tad biased in my high opinion of their products. Your mileage may vary.