Right-click a shortcut ->select Properties ->Shortcut Key ->Press a key combination.
Tried WinKey-Letter combination, but I have to use Ctl-Alt-letter = AltGr-Letter.
Do that for your most common apps, and it really speeds up your work! Now you don't have to go thru Start Menu or don't have to clear the desktop anymore to open something.
I assigned the links form the Start Menu, so I could clean up the desktop too

The combinations are real easy, I made:
AltGr-P = Pulsar
AltGr-C = Cubase
AltGr-F = Fruityloops
AltGr-E = Explorer
...
Also check your Winhelp on Keyboard Shortcuts. There's a lot of keyboard shortcut preset in Windows.
the atom.